Major depressive disorder (MDD) is characterized by significant and persistent depressed mood as the main clinical symptom, and is the most common type of mood disorder.
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Today, we discuss a research paper published by a client of Cyagen Biosciences as an example to show you the foundational ideas of successful preclinical research on gene therapy for cardiovascular disease.
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Chronic Kidney Disease (CKD) is characterized by the gradual loss of renal function and progression of renal fibrosis, and is a high-risk factor of end-stage renal disease (ESRD).
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Engineered nuclease-mediated genome editing, especially CRISPR, has emerged as a promising technology which can serve as an alternative to the conventional, embryonic stem (ES) cell homologous recombination-based generation of animal models.
CRISPR, which stands for “Clustered regularly interspaced short palindromic repeats,” works alongside Cas proteins to form the CRISPR-Cas complex – a biological technology originally derived from a prokaryotic adaptive immunity system. To show how this process works, our video introduces the individual components of a CRISPR-Cas complex using the SHANK3 gene as an example.
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Knockout mice have been essential for gaining proper understanding of gene function, studying human disease mechanisms, and accelerating drug development - playing an important role in biomedical advancements across a variety of research areas. With the development of gene editing technology, knockout (KO) mice become increasingly accessible for researchers worldwide. In this article, we review the basic information on knockout mice research, application examples, and the development process for custom KO mouse models.
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Several mutations in APOE (Apolipoprotein E) have been identified to not only increase the risk of developing AD, but other neurological and cardiovascular diseases. As scientists continue to evaluate potential therapies for AD, we hope to provide insights into various genes, related pathways, and research accomplishments in every Gene of the Week article. Herein, we summarize the current research progress on APOE functionality and review its role in Alzheimer's disease (AD).
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Specific mutations in TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) have been confirmed to increase the risk of developing late-onset AD. Here, we review the current data detailing the function of TREM2 and its role in Alzheimer's disease (AD).
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The rapidly growing branch of biomedical research known as translational medicine is aimed at the practical problems from clinical patients. A combination of molecular, cellular, and animal models in related basic and preclinical studies can help address the problems of translational research. Therefore, a major strategy of translational medical research is to combine the basic laboratory studies with the preclinical animal experimental research and rapidly move into clinical application.
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Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder, which is affecting 20 to 30 million individuals worldwide now. Currently, no effective therapies to treat or cure this disease were developed. In this review, we discuss the current research and understanding of the PSEN1 gene and its mutation in causing familial Alzheimer's disease (FAD).
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![[Gene of the Week] Alzheimer's Disease and Genes - APOE (Apolipoprotein E)](https://apac.cdn.cyagen.com/media/uploads/157x118-APOE.jpg)
![[Gene of the Week] Alzheimer's Disease and Genes - TREM2](https://apac.cdn.cyagen.com/media/uploads/157x118-TREM2.jpg)
![[Gene of the Week] Alzheimer's Disease and Genes - PSEN1 (Presenilin 1)](https://apac.cdn.cyagen.com/media/uploads/PSEN1_基因-TB小图.jpg)